Severin is interested in species-specific adaptations with a focus on gene regulation as its cause. Studying gene regulatory innovation in human brain development, he uses a Massively Parallel Reporter Assay (MPRA) to query the effects of human-specific substitutions on regulatory function in human neural stem cells, the main proliferative cell type of the developing brain. He integrates the results with large scale genomic data that he analyzes with both traditional statistics and machine learning approaches.
Severin did his undergraduate studies at the University of Heidelberg, Germany, and Uppsala University, Sweden, and earned a PhD in evolutionary genetics from Uppsala University in 2015. He joined the lab in 2016 and is supported by a fellowship from the German Research Council (DFG).
Personal website: http://severinevo.github.io/